| Spencer, Lee | Lee Spencer | Actor | 2011 | 1 | |
| Spencer, M. | M. Spencer | Designer | 1939 | 1 | |
| Spencer, M.E. | M. E. Spencer (M.E. Spencer) | Actor | 1909 | 1 | |
| Spencer, Mallory | Mallory Spencer | Actor | 2018 | 1 | |
| Spencer, Marian | Marian Spencer | Actor | 1939 | 1 | |
| Spencer, Nancy | Nancy Spencer | Director | 1943 | 1 | |
| Spencer, Sally-Jane | Sally-Jane Spencer | Actor | 1970 | 2 | |
| Spengler, Katharina | Katharina Spengler | Actor | 1998 | 1 | |
| Spengler, Simone | Simone Spengler | Actor | 1993 | 1 | |
| Spengler, Volker | Volker Spengler | Actor | 2011 - 2014 | 2 | |
| Spennert, Jenny | Jenny Spennert | Actor | 1896 - 1898 | 3 | |
| Spenser, Jeremy | Jeremy Spenser | Director | 1987 | 1 | |
| Spera, Miriam | Miriam Spera | Actor | 2011 | 1 | |
| Speranskaja, E. | E. Speranskaja | Actor | 1938 | 1 | |
| Speranza, Anthony, T. | Anthony T. Speranza | Actor | 1985 | 1 | |
| Speranza, Rolando | Rolando Speranza | Adaptation | 1994 | 1 | |
| Sperati-Jordan, Lulli | Lulli Sperati-Jordan | Actor | 1893 - 1903 | 7 | 1 |
| Sperati, Aagot | Aagot Sperati | Actor | 1929 - 1957 | 13 | |
| Sperati, Octavia | Octavia Sperati | Actor | 1877 - 1911 | 63 | 1 |
| Sperati, Paolo | Paolo Sperati | Composer | 1856 - 1866 | 5 | 1 |
| Sperati, Robert | Robert Sperati | Actor | 1907 - 1926 | 23 | |
| Sperduto, Al | Al Sperduto | Actor | 1959 | 2 | |
| Spergel, Mark | Mark Spergel | Actor | 1978 | 1 | |
| Sperli, Alessandro | Alessandro Sperli | Actor | 1968 | 1 | |
| Sperlì, Valentina | Valentina Sperlì | Actor | 2016 - 2018 | 42 | |
| Sperlich, Leo | Leo Sperlich | Actor | 1916 | 1 | |
| Sperling, Erich | Erich Sperling | Actor | 1919 | 1 | |
| Sperling, Martha | Martha Sperling | Actor | 1918 | 1 | |
| Sperre, Ann Toril | Ann Toril Sperre | Actor | 2002 - 2003 | 5 | |
| Sperry, Adam D. | Adam D. Sperry | Sound Designer | 1992 | 1 | |
| Sperstad, Kari Tone | Kari Tone Sperstad | Actor | 2008 | 1 | |
| Spertāls, Arvīds | Arvīds Spertāls | Designer | 1924 | 1 | |
| Speth, Rachel | Rachel Speth | Actor | 2022 | 1 | |
| Spethmann, Richard | Richard Spethmann | Actor | 1919 - 1938 | 5 | |
| Spevâkin, Sergej | Sergej Spevâkin | Set Designer | 2022 | 1 | |
| Spevâkina, Oksana | Oksana Spevâkina | Costume Designer | 2022 | 1 | |
| Speyer, George, G. | George G. Speyer | Actor | 1932 | 1 | |
| Speyer, Ruth | Ruth Speyer | Actor | 1948 - 1949 | 2 | |
| Spicer, Ben | Ben Spicer | Lighting Designer | 2000 | 1 | |
| Spicer, Jackie | Jackie Spicer | Actor | 2015 | 1 | |
| Spichiger, Kirsten | Kirsten Spichiger | Actor | 2002 | 1 | 1 |
| Spichtig, R. | R. Spichtig | Actor | 1998 | 1 | |
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